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Agnogenic Metaplasia
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Agnogenic Myeloid Metaplasia

What is Agnogenic Myeloid Metaplasia?

Agnogenic myeloid metaplasia is a condition that occurs when the bone marrow is scarred, making it less likely to manufacture blood cells. When the bone marrow does not function properly, the spleen and liver will produce blood cells. As a result, the spleen and liver may become enlarged.

Agnogenic myeloid metaplasia usually develops slowly. It most often occurs in people 50 years old and older. Agnogenic myeloid metaplasia leads to progressive bone marrow failure with severe anemia.

Most people with agnogenic myeloid metaplasia become dependent on blood transfusions for survival.

Agnogenic myeloid metaplasia is also called, AMM, primary idiopathic myelofibrosis, and myelosclerosis.

Symptoms of Agnogenic Myeloid Metaplasia

The most common symptoms of Agnogenic myeloid metaplasia are:

  • rapid heart beat
  • paleness
  • enlarged spleen
  • night sweats
  • weight loss
  • stuffed feeling after eating

Treatments options for Agnogenic Myeloid Metaplasia

Medications can help treat Agnogenic myeloid metaplasia but an allogeneic stem cell transplantation is needed for a cure.

Long Term Outlook

Unfortunately, Agnogenic myeloid metaplasia gets worse as the disease progresses. When the spleen the spleen is enlarged, blood platelets may become trapped in the spleen. If this occurs, your doctor may suggest surgical removal of the spleen.

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