Ménétrier's Disease

Ménétrier’s disease causes giant folds of tissue to grow in the wall of the stomach. The stomach tissue may be inflamed and may contain ulcers. Ménétrier’s disease also causes glands in the stomach to waste away and causes the body to lose fluid containing a protein called albumin. It increases a person’s risk of stomach cancer.

Ménétrier’s disease is quite rare. People who have it are usually men between ages 30 and 60. The cause of is unknown. It is also called giant hypertrophic gastritis, protein losing gasteropathy, or hypertrophic gastropathy.


Symptoms include:

  • pain or discomfort and tenderness in the top middle part of the abdomen
  • loss of appetite
  • nausea
  • vomiting
  • diarrhea
  • vomiting blood
  • swelling in the abdomen
  • ulcer-like pain after eating

Diagnosis of Ménétrier’s Disease

Ménétrier’s disease is diagnosed through x rays, endoscopy, and biopsy of stomach tissue. Endoscopy involves looking at the inside of the stomach using a long, lighted tube that is inserted through the mouth. Biopsy involves removing a tiny piece of stomach tissue to examine under the microscope for signs of disease.

Treatment options

Treatment for Ménétrier’s disease may include medications to relieve ulcer symptoms and treat inflammation, and a high-protein diet. Part or all of the stomach may need to be removed if Ménétrier’s disease is severe.